Sonam Agarwal
Banasthali University, India
Title: Concomitant exposure of bacoside A and bromelain relieves dichlorvos toxicity in mice serum
Biography
Biography: Sonam Agarwal
Abstract
Current study emphasizes the toxic eff ects of dichlorvos on serum in terms of oxidative stress. Meanwhile, a protective action of bacoside A and bromelain was investigated against the biochemical alterations in serum. Experimental design included six groups of mice: Saline was given as a vehicle to the control mice (group I). Mice belonging to groups II, III and IV were administered with dichlorvos (40 mg/kg b.w.), bromelain and bacoside A, respectively. Fift h group received a combination of bromelain and bacoside A. In group VI, bacoside A and bromelain were administered 20 minutes prior to exposure of dichlorvos. Th iobarbituric acid reactive substances (TBARS), protein carbonyl content (PCC), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH) level were used as biochemical test of toxic action for dichlorvos intoxication. Signifi cantly increased TBARS and PCC level in second group suggests that dichlorvos enhances the production of free radicals in serum of mice (p<0.05). Antioxidants treatment signifi cantly decreased the levels of TBARS and PCC (p<0.05). Dichlorvos administration causes a signifi cant reduction in the level of CAT, SOD, GPx and GSH (p<0.05) which was restored signifi cantly by co-administration of bromelain and bacoside A in dichlorvos exposed mice (p<0.05). Treatment of bromelain and bacoside A in combination served as better scavengers of toxicity induced by dichlorvos.