Pierre Eftekhari
Inoviem Scientific, France
Title: Individualised clinical toxicology: Physiological intermolecular modulation spectroscopy (PIMS), a technology to forsee drugs efficacy prior to administration
Biography
Biography: Pierre Eftekhari
Abstract
Toxicology today is in need of new insight. In air of individualised medicine the relation between desired clinical eff ect and toxic or side-eff ects should be considered simultaneously. Genomics, proteomics, metabolomics and omics in general, although extremely valuable, are globally lacking clinical relevance. Th erefore, there is a need for new methodologies and new tools enabling us to make a bridge between predicted omics-based drug toxicity and clinics. Here, I shall present Physiological Intermolecular Modulation Spectroscopy (PIMS) a cutting edge techology meant to stratify the patients as responders or non-responders in regard to a pharmacological active agent. PIMS provides individual fi ngerprints based on drug-induced macromolecular modulation directly on human tissue extracts. I will explain the scientifi c background of PIMS and present the results from two diff erent clinical studies (transversal and longitudinal), using peripheral blood mononuclear cells (PBMC) isolated from patients with ulcerative colitis and Crohn’s disease for the prediction of infl iximab effect.
