Layla E. Borham
Umm Al-Qura University, Saudi Arabia
Title: The effect of proton pump inhibitors on bone mineral density in rats
Biography
Biography: Layla E. Borham
Abstract
Background: Increased concerns rose towards the side effects of chronic use of proton pump inhibitors (PPIs). The relationship between prolonged use of PPIs and bone metabolism, is still not totally established.
Objectives: Examine the association between the use of (PPIs) and the risk of development osteoporosis.
Methodology: 180 adult male rats were assigned to three groups (60 rats each). Group I served as control; whereas, group II (a, b), (i.p) omeprazole 20 mg/kg/day was administered for 4 and 8 weeks respectively; group III (a, b), (i.p) omeprazole 40 mg/kg/day was given for the same period. At the end of drug treatment, twenty rats from each subgroup were examined for bone mineral density (BMD), bone mineral content (BMC), serum calcium, phosphorus, parathormone, tartrate resistant acid phosphatase type 5b (TRACP5b), insulin-like growth factor 1(1GF-1) and Osteoprotegerin (OPG). The remaining 10 rats from each subgroup were left without treatment for the next 4 weeks to detect the reversal effects of the drug.
Results: BMD and BMC decreased in a dose and time dependent manners, with recovery. Serum calcium and phosphate decreased at the dose 40mg/kg for 8 weeks, with recovery of calcium after discontinuation of therapy but not phosphate. Parathormone increased compared to control with no recovery. TRACP5b increased at 20, 40 mg at 8 weeks with no recovery. IGF-1decreased in dose and time dependent manner, recovery only for 20 mg for 4 weeks. OPG shows no change.
Conclusion: The chronic use of high doses of omeprazole could adversely affect bone homeostasis.