Liping Yang
Beijing Hospital, P.R. China
Title: Vancomycin-induced skin eruptions with susceptibility alleles to SJS/TEN
Biography
Biography: Liping Yang
Abstract
What is known and objective: The glycopeptide antibiotics, vancomycin and teicoplanin, are the mainstay of therapy forsevere gram-positive organisms such as methicillin-resistant Staphylococcus aureus. We report a case of Stevens–Johnson syndrome (SJS) induced by sequential therapy with teicoplaninand vancomycin, in a patient with chronic obstructive pulmonary disease (COPD). Case summary: A 74-year-old Han Chinese with 1-year history ofCOPD was admitted for treatment of infective endocarditis. After teicoplanin therapy for 12 days, he developed pruritus andmaculopapular over his trunk and limbs. His rash spread rapidlyto most parts of the body surface area, 7 days after his anti-infection therapy was switched to vancomycin. This was stopped, but he developed SJS when teicoplanin was reintroduced.This patient recovered from his drug eruptions when both teicoplanin and vancomycin were stopped. Pharmacogenetic analyses revealed he was heterozygous with respect to two variants (rs2844682 of MUC21 and rs750332 of BAG6). What is new and conclusion: Cross-reactivity between vancomycinand teicoplanin is rare. SJS attributable to sequential treatment with these two antibiotics has not been reported previously. Care should be taken when prescribing vancomycin in patients with a previous documented skin eruption to teicoplanin, especially in those who carry any susceptibility alleles to SJS/TEN.